Differin Gel is the FIRST and ONLY FDA-approved full prescription strength retinoid acne treatment now available without a prescription. Until now, 99% of all OTC acne medications in the US used only two different types of active ingredients. Differin Gel contains adapalene, a multi-benefit dermatologist recommended retinoid that clears and prevents acne which helps restore your skin’s natural tone and texture. It is the newest active ingredient in OTC acne in over 30 years. Now you can clear your acne with the power of Rx.Directions:A 45 g tube of Differin can be used once a day, every day, up to a 90 day supply. A 15g tube of Differin can be used once a day, every day, up to a 30 day supply. 1. CLEANSE: Wash your face with a gentle, non-drying cleanser like Differin Balancing Cleanser.2. TREAT: Differin Gel is not used in the same way as a spot treatment. In order to get the best results,spread a thin layer over your face, once a day, every day. 3. MOISTURIZE: To help maintain healthy skin, use a moisturizer like Differin Balancing Moisturizer after each application. Use of a moisturizer may help decrease dryness and other signs of irritation..Ingredients:Active ingredient: Adapalene 0.1% (retinoid)Inactive ingredient: carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. May contain hydrochloric acid to adjust pH.